Can Multisite SHC be integrated with Individual Indexers?

We do not have Multisite SH and Indexer Cluster in our environment. We have like really huge no of Hosts ( Indexers & SH) and many deployments, like 110 Indexers with 22 SHC , 25 Indexers with 12 SHC. We only maintain SHC Cluster( Search heads are from two different Data centres ) and each Indexer host is a separate Instance Can we enable multisite SHC clustering without an Indexer Cluster? - i.e Retain Indexers as separate individual hosts but enable SHC with mulitiste clustering across two sites with Individual search peers. Is this possible?